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However, there are currently no explicit guidelines outlining optimal supplementation approaches

3 The metabolic plasticity in this context poses challenges for cancer therapies targeting the Warburg effect, as complete blockade of glucose uptake often proves to be unfeasible

Of note was the large (8- to 13-fold) increase in the conversion of E1 into its hydroxylated and methylated forms compared to the 2- to 5-fold increase observed for most other metabolite ratios