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o Novo Nordisk has shown strong confidence by advancing both subcutaneous and oral forms of amycretin into a comprehensive Phase 3 program (AMAZE) expected to start in Q1 2026 A Broader, Segmented Portfolio Approach: The company is now clearly articulating a more sophisticated strategy that goes beyond a simple "efficacy race." o Cagrilintide (monotherapy) is being advanced into a dedicated Phase 3 program (RENEW) in Q4 2025

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125 The functional role of the N domain is unknown, but it may play a role in enzyme regulation

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Glutamine facilitates enteral absorption of nutrients and electrolytes in animals with experimental diarrhea (35)