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However, if extremely high doses are given for a long time, pyridoxine can cause nerve damage leading to numbness or tingling in the hands and feet (peripheral neuropathy)

Additionally, SNPs in seven genes, namely, thymidylate synthase ( TYMS ), methionine synthase ( MTR ), methionine synthase reductase ( MTRR ), methylenetetrahydrofolate reductase ( MTHFR ), dihydrofolate reductase ( DHFR ), cystathionine beta-synthase ( CBS ), and betaine-homocysteine methyltransferase ( BHMT ), are associated with the folate and methionine cycle [11, 12, 18,19,20,21]