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The abnormal aggregation of -syn can disrupt mitochondrial homeostasis through several mechanisms: (1) Inhibition of mitochondrial membrane fusion: In vitro experiments have demonstrated that the direct interaction of -syn with the mitochondrial membrane can lead to mitochondrial fragmentation and activation of the apoptotic pathway (Panicker et al., 2021)

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doi: 10.3390/ijms22010330 139 Silva FigueiredoPCarla InadaAMarcelinoGMaiara Lopes CardozoCde Cssia FreitasKde Cssia Avellaneda GuimaresRet al