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as a single agent for the maintenance treatment of patients with locally advanced or metastatic, non-squamous NSCLC whose disease has not progressed after four cycles of platinum-based first-line chemotherapy

Beyond physical manifestations, B12 deficiency can severely impact mental and emotional health, leading to irritability, loss of appetite, memory trouble, and depression

As a result, oral supplementation may not be sufficient and injections may be necessary

Tchernof A, Desprs J-P

6 Treatment There is broad expert agreement that optimal management of fibromyalgia involves first-line non-pharmacologic interventions, prioritizing lifestyle interventions (eg, diet, exercise, and sleep improvement) as well as patient education, psychotherapy, and mindfulness or other stress management practices