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The downstream effects on adipose-tissue gene expression, methylation status, and NAD + pool dynamics are interpreted in the published literature as the basis for the metabolic phenotype observed in mouse models

[DOI] [PubMed] [Google Scholar] 167.Friedman SL, Roll FJ, Boyles J, Arenson DM, Bissell DM

But - clinical trials aren't substantial, it's still not approved for use (indicating more safety data is warranted), most work is pre-clinical and or done with rodents not humans and given its ability to upregulate human growth hormone and angiogenesis (create new blood vessels), someone with a history of cancer would be advised to take serious precautions

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