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10.1038/s42255-021-00466-9 87 PamplonaR.BarjaG

Fatty liver disease primarily develops through metabolic pathways involving excess fat accumulation in liver cells (hepatocytes), most commonly associated with obesity, type 2 diabetes, excessive alcohol consumption, and metabolic syndrome

Treatment of HepG2 cells with different concentrations of NFT or DEM for 24 h led to a concentration-dependent increase in Nrf2 and GCLC protein levels, whereas no significant change was observed in the levels of the modifier subunit, GCLM (Fig