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Conversely, in the adaptive immune system, lack of succinate appears to be of particularly relevance in breaking tissue tolerance and causing inflammation ( Figure 3 )

& Thomas, J

These results were confirmed in vivo , with an estimated lower plasmatic concentration of quercetin (nM) (similarly to other studies (7173)) during which quercetin reduced RV-RNA at 1 day post-infection, modulated KC, MIP-2, TNF-a, and MCP-2, decreased virus-induced airway hyper-responsiveness, and modulated IFNs (IFN- and IFN-2) (70)

10.1161/CIRCULATIONAHA.122.062132 [DOI] [PubMed] [Google Scholar] 107

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