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Research dose/evidence: Some cosmetic studies show Acmella extract (the source of spilanthol) improves wrinkle appearance, but there are fewer large clinical trials than for retinoids or peptides (there never are with botanical extracts)

Beetroot juice improves in overweight and slightly obese men postprandial endothelial function after consumption of a mixed meal

Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism

Pharmacological agents such as ergothioneine acid reduce the SSG of NF-B-dependent Wnt5a-sFlt1, improving post-MI outcomes by preserving GRX1 activity and myocardial integrity (84)