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Because the chronic diseases associated with GSH deficiency are also the leading causes of death today, it serves to reason that even small potential health benefits across many chronic illnesses would have a meaningful impact in decreasing population-wide morbidity and mortality

206 In various brain areas, including the cerebral cortex, hippocampus, amygdala, and dorsal cochlear nucleus (DCN), the transporter is abundantly present in excitatory neurons, playing a crucial role in channeling zinc into presynaptic vesicles

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However, the high total-body content of glutathione (probably in the range of 40 to 80 gm in a 70 kg adult) and the relatively short half-life of this reactive and metabolically important compound (4 to 10 hours in most tissues) render glutathione replacement extremely difficult to achieve in practice

A multiinstitutional survey of the Wiskott-Aldrich syndrome