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Even in early-stage disease, experimental and clinical data show that tubular stress biomarkers and fibrosis-associated molecules are detectable in urine and tissue and are associated with subsequent decline in eGFR ( Microvascular injury and capillary rarefaction are integral components of this process

[DOI] [PubMed] [Google Scholar] 305.Wang Z, Jiang H, Chen S, Du F, Wang X

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2.3.2 Inflammatory mediators (Cytokines, Chemokines) The inflammatory response that accompanies I/R injury is orchestrated by a number of inflammatory mediators, including cytokines, chemokines, and adhesion molecules