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However, the underlying mechanisms of DKD remain elusive

The last review in 2012 indicated HBOT had a static effect or a potentially receding effect, the latter occurring in very hypoxic tumors such as glioblastoma multiforme

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Growth factors like nerve growth factor (NGF), Stem cell factor (SCF), and hepatocyte growth factor (HGF) support melanocytes, while transforming growth factor- (TGF-) and glucocorticoid receptor (GR) inhibit them