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Most patients lose 1-2kg monthly once optimized on their medication

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In one published clinical trial (NCT00233519) involving 15 participants, SomatoKine (Iplex), a combination of IGF-1 and IGF-1 binding protein-3, was administered to patients with myotonic dystrophy type 1, indicating that SomatoKine could enhance lean body muscle mass and metabolism without significantly improving muscle strength or function [442]

Although GLP-1RAs have inhibitory effect on sodium hydrogen exchanger-3 in tubules, it is unclear that renoprotective effect of GLP-1RAs is attributable to hemodynamic effect [44]