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Research has identified several natural compounds, often linked to senolytic effects, that can enhance the activity of SIRT1 and SIRT2

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Hong S, Moreno-Navarrete JM, Wei X, Kikukawa Y, Tzameli I, Prasad D, Lee Y, Asara JM, Fernandez-Real JM, Maratos-Flier E, Pissios P. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med. 2015 Aug;21(8):887-94. doi: 10.1038/nm.3882. Epub 2015 Jul 13. PMID: 26168293; PMCID: PMC4529375

Animal studies have suggested a potential link to thyroid tumors, though this has not been proven in humans (FDA prescribing information for Wegovy)

This was confirmed by the strong anti-IgG4 staining on both TCM and TEM 3 days after anti-PD1 treatment ( Figure 2F , right panel)