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TABLE 2 Research on the influence of the Gut-microbiota-lung Axis on the treatment response of lung cancer

While PGRMC1 is implicated in cell proliferation and cholesterol biosynthesis 20,21 , the structural basis on which PGRMC1 exerts its function remains largely unknown

Despite the unclearly delineated molecular targets of CHE, extensive research in this area provided continuously fresh data exploitable in the clinic while addressing the present requirement for further studies such as toxicological studies, combination medication, and the development of novel chemical methods or biomaterials to extend the effects of CHE or the development of its derivatives and analogs, contributing to the effective transformation of this underestimated anticancer drug into clinical practice

Numerous studies confirming honeys antimicrobial, anti-inflammatory, and tissue-regenerative properties have prompted researchers to explore its potential in managing complex chronic diseases, including cancer

10.1038/aps.2009.112 143 YabeT.TuchidaH.KiyoharaH.TakedaT.YamadaH