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Clinically, the concomitant use of resveratrol (RSV) with docetaxel (DTX) has been observed to suppress Bcl-2, amplify apoptosis, and necroptosis, thereby mitigating the drug resistance often associated with DTX monotherapy and elevating therapeutic efficacy (164)

Impaired glycolysis can be detrimental to neurons, especially during high energy demand

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Stockler-Ipsiroglu S, van Karnebeek C, Longo N, Korenke GC, Mercimek-Mahmutoglu S, Marquart I, Barshop B, Grolik C, Schlune A, Angle B, Araujo HC, Coskun T, Diogo L, Geraghty M, Haliloglu G, Konstantopoulou V, Leuzzi V, Levtova A, Mackenzie J, Maranda B, Mhanni AA, Mitchell G, Morris A, Newlove T, Renaud D, Scaglia F, Valayannopoulos V, van Spronsen FJ, Verbruggen KT, Yuskiv N, Nyhan W, Schulze A (2014) Guanidinoacetate methyltransferase (GAMT) deficiency: outcomes in 48 individuals and recommendations for diagnosis, treatment and monitoring

Continuous administration of a powerful growth factor can lead to receptor downregulation, diminishing its effects over time