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it was calculated using the following equation: where, Q s is the cumulative drug permeation per unit area (gcm 2 ), C sn is the drug concentration measured in the receptor fluid at n sampling intervals (gmL 1 ), V S is the volume of the receptor pool (13 mL), is the cumulative drug concentration in the receptor fluid, S is the sampling volume (2 mL), and A S is the effective diffusion area (1.0 cm 2 )

[DOI] [PubMed] [Google Scholar] 217.Yao J., Li X., Lin M., Han Z., Wang X., Guo J., Wu B., Xia J

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Cancer 133 UekiT.FujimotoJ.SuzukiT.YamamotoH.OkamotoE

[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Soliman H, Theret M, Scott W, Hill L, Underhill TM, Hinz B, Rossi FMV