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Disclosures: Qing-Lei Zeng: Nothing to Disclose, Ru-Yue Chen: Nothing to Disclose, Xue-Yan Lv: Nothing to Disclose 431 INNATE IMMUNITY PLAYS AN IMPORTANT ROLE IN THE INACTIVE CHRONIC HBV CARRIERS WITH POSITIVE HBEAG AND HIGH HBV DNA DURING TAF TREATMENT Qiumin Luo 1 Wenxiong Xu 1 Yeqiong Zhang 1 Chan Xie 1 Liang Peng 1 , 1 Sun Yat-sen University Background: The innate immune mechanisms that affect the efficacy of TAF treatment in chronic HBV carriers with normal ALT and high HBV DNA load deserve more exploration

Aquatic Therapy supports lymphatic drainage and joint health

To directly determine whether this hyperphosphorylation is CDK11-dependent, we first depleted SNIP1 to induce SF3B1 phosphorylation and subsequently treated cells with OTS964 (Fig