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Second, the chemistry should be carried out under aqueous denaturation conditions to avoid aggregation and kinetically trapped folding intermediates

For example, single-cell sequencing has revealed that neurons upregulate glucose transporter GLUT3 and hexokinase 2 gene expression under oxidative stress, while live-cell imaging directly visualizes mitochondrial reorganization and glycolytic enzyme relocalization during surges in energy demand

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Rodgers A, Gauvin D, Edeh S, Allie-Hamdulay S, Jackson G, Lieske JC (2014) Sulfate but not thiosulfate reduces calculated and measured urinary ionized calcium and supersaturation: implications for the treatment of calcium renal stones