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However, if D1 activity is low, inactivation of thyroid hormone by sulfation is reversible due to expression of sulfatases in different tissues and by intestinal bacteria (179)

A recent study has demonstrated that targeted inhibition of glutathione and thioredoxin antioxidant pathways can synergistically kill cancer cells, suggesting that antioxidant systems are important for the initiation and progression of cancer cells [46]

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The organism that expresses the mutant synthetase can then be genetically programmed to incorporate the unnatural amino acid into any desired position in any protein of interest, allowing biochemists or structural biologists to probe or change the protein's function