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for instance, 42.9% of methotrexate-refractory RA patients failed to meet ACR criteria after 12 weeks of adalimumab (10)

Andrologia 2012;44(3):157-163

The LOAEL reported in this study was 10 mg/kg body weight, showing a slight, but significant increase in SDH activity and mild hepatic centrilobular vacuolization (Bruckner et al., 1986)