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In the course of research whether and how naringenin (NGN) would be able to prevent the mitochondria-related bioenergetics and redox dysfunctions induced by methylglyoxal (MG) in the human neuroblastoma SH-SY5Y cells, researchers found that NGN caused mitochondrial protection by an Nrf2/GSH-dependent manner (de Oliveira et al., 2019)

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The brain is constituted by a preponderance of microglia and astrocytes, these glial cells are essential in the Central Nervous System (CNS), with microglia functioning as innate immune cells involved in surveillance and defense, while astrocytes modulate neuronal communication, maintain the extracellular environment, and regulate inflammatory signaling (Garland et al., 2022) Both brain cells are able to produce pro- and anti-inflammatory cytokines (Schwarz and Bilbo, 2012)

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