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However, it is important to note that although simulated nasal fluid was employed in this investigation to replicate the nasal environment, there may be discrepancies with the actual conditions in the human nasal cavity, particularly concerning aspects such as nasal mucus, enzymatic breakdown, and mucociliary clearance

They also promote macrophages to polarize into the M1 phenotype and stimulate a positive feedback loop, increasing cytokine production and killing more islets (8)

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