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Marcus, E., Stone, P., Thorburn, D., Walmsley, M

The Risks Translation Gap: From Mice to Humans A persistent challenge across peptide research is the failure of dramatic rodent results to replicate in humans with only 1.5% of positive mouse studies translating to FDA approved therapeutics

Poor sleep increases ghrelin (hunger hormone) and decreases leptin (satiety hormone), directly undermining dietary adherence

These include improvements in learning and memory, reductions in amyloid plaques and tau phosphorylation, attenuation of cortical and hippocampal neuronal loss, increased neurogenesis, improved synapsis number and plasticity, reduced brain oxidative stress, cerebral anti-inflammatory activity and improved brain insulin receptor localisation and signalling

The second reaction adds a glycine to the Gamma-glutamylcysteine to produce the tripeptide glutathione