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Research on Phase II detoxification estimates that glutathione conjugation is responsible for detoxifying up to 60% of all therapeutic drugs, environmental toxins, and heavy metals

A panel of innate immune cell-related markers was used, and ssGSEA was used to calculate infiltration scores based on RNA-seq data

Other organ disease Depending on the degree of organ involvement, oral or systemic steroids may be required

The acquired resistance to ICB treatment might be due to cancer cell-intrinsic and -extrinsic changes, including the loss of MHC class I on cancer cells (175, 176), genetic mutations that diminish T-cell infiltration (177, 178), or host microbiota (179182)

Low serotonin levels can result in sadness, lack of motivation, or even depressive symptoms