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Use resistance training to amplify the benefit

The principal conformational changes are the ~54 outward splaying of TM1a and further unwinding of the intracellular side of TM5 in the inward-open conformation (Fig

The vital role of selenium metabolism in maintaining cartilage homeostasis is expected, considering its critical involvement in regulating cellular processes such as chondrogenic differentiation of progenitor cells, maintenance of redox homeostasis and DNA damage repair in chondrocytes, which are covered in the next section