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typically, endorphins are derived from pro-opiomelanocortin, enkephalins are derived from proenkephalin and prodynorphin precursors, and dynorphins are derived from prodynorphin [22]

In this work, GSH-CDs was demonstrated as an effective candidate for delaying disc degeneration, which effectively improves the conditions of malignant oxidative stress within the NPCs microenvironment in a multiple cascade-like activities manner, that is, inhibits the senescence of NPCs induced by excessive accumulated ROS via exerting multiple antioxidant enzyme activity