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Reversible and asymptomatic elevations in transaminases were the primary adverse effects when CB-839 monotherapy was used to treat hematologic malignancies and solid tumors in clinical trials (226228)

Finally, without a well-functioning guardian of the genome, the complete dysregulation of genome stability, cell homeostasis and induction of cancer development may occur

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Mutations and/or deletions of mtDNA can have deleterious effects on mitochondrial energy homeostasis

Angiotensin II protects against -synuclein toxicity and reduces protein aggregation in vitro