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The "LR3" modification (a substitution at position 3 and an arginine extension) reduces IGF-1 LR3's affinity for IGF-binding proteins (IGFBPs)

Pregnancy and breastfeeding are absolute contraindications

Reck M, Rodrguez-Abreu D, and Robinson AG, et al (2016) Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer N Engl J Med 375 (19) 18231833 PMID: 27718847 5