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Studies have found that fentanyl causes inflammation and increases the levels of total mercaptan, acetylcholine, butyrylcholine, and paraoxonase-1, leading to neuronal cell death, and the level of TNF- in neuronal cells increased by 2.3 times after fentanyl administration 65

Journal of Physiology, 593 (24), 5215-5217

Glutathione is found in two forms, a monomer that is a single molecule of the protein, and a dimmer that is two of the single molecules joined together

Any time acetaminophen is taken, at least 600 mg of N-acetyl cysteine should be taken along with it to help protect against liver toxicity

Therefore, the short duration of the majority of animal models of CIPN likely regard the acute phase only [181]