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If no adverse reactions occur, the dose can be slowly titrated up over several weeks until the target therapeutic level is reached

Upon the challenge of oxLDL, ATF6 dissociates from the ER membrane, moves into the Golgi apparatus, where it is cleaved into its active form (p50-ATF6), which subsequently translocates into the nucleus to regulate target genes, such as GRP78 and XBP-1 (156)

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When installed some trial and error adjustment of the float valve may be required to balance the makeup water with tower operation