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FMT in animal models has been found to reduce the abundance of the Akkermansia genus (in phylum Verrucomicrobia) and increase the abundance of the Prevotella genus (in phylum Bacteroidetes) in gut microbiota (Tankou et al., 2018b), which is in line with findings of decreased gut Akkermansia after probiotic interventions and increased gut Prevotella after first-line disease-modifying treatments and time-restricted eating in MS patients (Jangi et al., 2016

Consistent with these biological roles, cytokine analysis revealed that EGCG-Zn significantly downregulated the pro-inflammatory cytokines IL-6 and TNF- while upregulating the anti-inflammatory cytokine IL-10 (Fig