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2012;7:e48777

Zinn AB, et al

It should be noted that although a growing number of studies have shown that amino acid metabolic reprogramming is widely present in the inflammatory microenvironment of multiple autoimmune diseases and is closely associated with the functional states of macrophages, current evidence also suggests that, in most diseases, alterations in amino acid metabolism are not necessarily primary drivers of disease onset, but may more likely reflect metabolically adaptive changes during immune cell activation and polarization