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Recent preclinical mouse models have shown that immune-targeting the xCT antigen can enhance the activity of a viral vectors-based vaccine against HER2, and reduces the growth of HER2+ breast cancer, frequency of CSCs and metastatic events (85)

Among individuals with MetS, the relative risks for mortality due to CHD and CVD were approximately four and three and a half, respectively (41)

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This variants association with lipedema suggests a potential genetic link, possibly altering lipid metabolism, adipogenesis, or hormonal regulation