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Circadian levels and rhythmicity of mRNA expression of core clock genes (CGs) and some clock-controlled genes (CCGs, Sirt1 , Nampt , Nmnat1 ), NAD + level, NAD + /NADH, and SIRT1 activity were determined in these liver tissues

Ruan H, Leibowitz BJ, Zhang L, Yu J

Additionally, another study indicated that CU activates the Wnt/-catenin signaling pathway by inhibiting the expression of GSK-3, which may be a key protein through which CU influences this pathway in PD (Zhang et al., 2011)

Moreover, the cost of its surgical treatment places a heavy strain on world healthcare [33]

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