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Our roGFP2 measurements confirm (i) that dynamic roGFP2 sensing (or the physiological glutathionylation/deglutathionylation of regular surface-exposed cysteinyl residues) requires a glutaredoxin activity, and (ii) that glutathionylated proteins or metabolites should be very transient redox species when GSH and glutaredoxins are present (unless they are stabilized by a kinetic uncoupling mechanism) 5,32,34,35,61,62,63,64

In this evaluation system, the read-out for a functional N-degron is the number of trichomes formed per leaf after the shift from permissive to restrictive temperature

In this context, the use of 5-MTHF, the bioactive form of folate, emerges as a promising alternative to folic acid

Statements Author contributions ASk: Conceptualization, Data curation, Supervision, Visualization, Writing original draft, Writing review & editing

Br J Pharmacol 119(8):15331540 Mehta R, Pascual M, Soroko S, Savage B, Himmelfarb J, Ikizler T, Paganini E, Chertow G (2004) Spectrum of acute renal failure in the intensive care unit: the PICARD experience