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doi: 10.1093/neuros/nyw101 95 TarditoSOudinAAhmedSUFackFKeunenOZhengLet al

Gallavan, R

They increased again in the acute-on-chronic phase.* Activity from Glutathione Stransferase (GST)a family of Phase II detoxification enzymesincreased significantly at 8 hours (acute) and at 4 and 8 hours (acuteonchronic).* Serum Antioxidant Reserve (SAR)a measure of the bodys overall capacity to neutralize free radicals and defend against oxidative stressincreased 32% within two hours of the first dose and rose 62% by day 28, with further significant increases during the acuteonchronic phase.* The results of this data suggest that Hepasil DTX supports optimized natural detoxification capacity by sustaining glutathione levels, vitamin C status, GST activity, and overall antioxidant reserve

Using mass spectrometry (MS) approach, we then showed that the resulting NCs bind carbonylated proteins through the formation of an oxime bond between the aminooxy-containing thiolated ligand on the NC and the carbonylated amino acid on the protein

12 , e1001903 (2014)