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In the central nervous system (CNS), lutein supports brain homeostasis through its antioxidant and anti-inflammatory properties, increasing interleukin-10 (IL-10) and reducing tumor necrosis factor- (TNF-)

Integration of these emerging tools with lipid peroxidation reporters, ROS probes, and single-cell transcriptomics will be essential for establishing the causal hierarchy of iron dysregulation in pathophysiological ferroptosis