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The authors reported that AOD-9604 stimulated lipolysis in isolated adipocytes and that chronic daily treatment in obese Zucker rats produced reductions in body weight gain of more than 50% relative to untreated controls over the treatment period, without effects on insulin sensitivity or IGF-1 levels [3]

doi: 10.1016/j.celrep.2021.109753 72 LachnerCSteinleNIRegenoldWT

The researchers commented, " Mean gross morphological and histopathological scores were significantly higher in Group 1 than in Groups 2, 3, and 4, and the scores were significantly lower in Group 4 than in Groups 2 and 3

To ensure consistency in the studys outcomes, they will also be instructed to avoid the use of other systemic medications that could interfere with the treatment protocol