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New approach methodology for assessing inhalation risks of a contact respiratory cytotoxicant: computational fluid dynamics-based aerosol dosimetry modeling for cross-species and in vitro comparisons

The AOD-9604 Vial is supplied as a sterile, lyophilized (freeze-dried) powder

Given that GCLM is the regulatory subunit of the GCL complex, we postulate that covalent targeting of C114 results in allosteric inhibition of GCLC catalytic enzyme activity