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Description

The main active component of Fructus Mori, M

Second, proline substitutions at positions 25, 28, and 29 reduce the tendency to form beta-sheet structures that lead to aggregation

however, lack of interactions from the catechol group, as observed in docked poses and MD analysis, predicted to cause weak or no mh-Tyr inhibition by comparison to other selected flavonoids (EC and CH) due to rapid oxidation in the catalytic pocket of the mh-Tyr protein