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Low levels of ergothioneine are correlated with neurodegeneration and cognitive impairment

A deep understanding and addressing the dysregulation of the NTFs-mitochondrial network holds promise for opening new avenues in the development of disease-modifying therapies, but it is essential to remain keenly aware of existing challenges

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91 found global decreases in chromatin accessibility in the RPE from early AMD globes and in the retina of advanced disease, which suggests that RPE dysfunction drives disease onset