glutathione s-transferase deficiency The role of S-transferases in human disease pathogenesis and their current inhibitors glutathione s-transferase deficiency S-transferases and

GSH is often referred to as the most important non-enzymatic antioxidant in cells, as it is essential in various antioxidant processes

This means that more methylfolate is diverted towards thymidine production, and less is available for methylation reactions.31 In particular, low methylfolate levels are associated with low glutathione.32 Glutathione is important for reducing oxidative stress and helping to halt the self-perpetuating peroxynitrite cycle

Ton et al., 2020

GSSG is widely believed to be involved in the oxidation of PDI, but it has been shown that the ER flavoprotein Ero1 catalyses the oxidation of PDI in vivo and in vitro (Frand & Kaiser, 1998, 1999

[DOI] [PubMed] [Google Scholar] Keppler D and Konig J (1997) Hepatic canalicular membrane 5: Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver