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Second, it wastes peptide

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Studies have also indicated that oxidative stress is increased in the serum of MS patients, suggesting a close association between MS and oxidative stress [115]

Intriguingly however, very recent data on anti-CD20 B cell depleting agents might be showing some efficacy in progressive MS, although the effect of peripheral B cell depletion on PIRA cannot be interpreted as independent of its effect on silencing acute/adaptive inflammatory activity (Kappos et al., 2020)