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As mentioned earlier in Section 4.2.12, vitamin B13 has not been studied alone, but only in combination with other vitamins, as demonstrated in two studies of major interest in the AD context

Laboratory Tests:During the initial treatment of patients with pernicious anemia, serum potassium must be observed closely the first 48 hours and potassium replaced if necessary

Cyperus rotundus mediated green synthesis of silver nanoparticles for antibacterial wound dressing applications

At week 32, that number approached 20%

Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization