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However, although our genetically engineered mouse model of RMC reproduces the aggressive and metastatic phenotypes observed clinically, there is no perfect equivalence between mouse models and human diseases, and thus, caution must be exercised when extrapolating these findings to the clinic

doi: 10.1136/gutjnl-2020-323020 105 ZuoTZhanHZhangFLiuQTsoEYKLuiGCYet al

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In medicine, tyrosinase is a key therapeutic target for treating a range of skin pigmentation disorders, including vitiligo 17 , hyperpigmentary 18,19,20,21 , and melanoma 22