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Sci Rep 6 , 37596 (2016)

Furthermore, we also showed that the transgene of nonmitochondrial (cytosolic) Gpx4 without MTS rescued cell death induced by the depletion of all isoforms of Gpx4 , while that of mitochondrial Gpx4 with MTS could not prevent it, indicating that nonmitochondrial (cytosolic) Gpx4 was an essential isoform in GPx4 deletioninduced cell death (39)