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Supplementary Table 3 (download XLSX MY-LC clinical and immunological data

Early pharmacokinetic studies suggested that when standard, unprotected glutathione was ingested, it was rapidly cleaved into its constituent amino acids (glutamate, cysteine, and glycine) by digestive enzymes like $\gamma$-glutamyltransferase and harsh stomach acids

Notably, eutylone caused time-dependent inhibition of CYP2D6 with K i = 4.2 M and k inact = 0.069 min 1 , and of CYP2B6 with K i = 32.9 M and k inact = 0.080 min 1 , without any measurable inhibition of UGT enzymes

However, there were no reported significant changes in total tau, phosphorylated tau, or the ratio of phosphorylated tau:total tau (Namjoshi et al., 2017)

in this situation, NAC reduces the risk of hepatotoxicity to 100 mg/L, the presence of renal failure or ARDS, or progression of the toxidrome despite alkalinization therapy (39)