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Sun exposure: Too much sun can increase melanin production in the skin, leading to pigmentation and darker under-eye areas

Table 18: Efficacy Results in Study JMCH Based upon prospectively defined criteria (modified Southwest Oncology Group methodology) the objective tumor response rate for pemetrexed plus cisplatin was greater than the objective tumor response rate for cisplatin alone

For in vivo or ex vivo studies (if employed in nonclinical contexts), consider potential biodistribution, clearance, and off-target interactions in experimental design