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in pure formulation, copper must be added exogenously to ensure activity

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Maintenance therapy with pemetrexed plus best supportive care versus placebo plus best supportive care after induction therapy with pemetrexed plus cisplatin for advanced non-squamous non-small-cell lung cancer (PARAMOUNT): a double-blind, phase 3, randomised controlled trial

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(2) Epigenetic intervention: Targeting epigenetic modifications can reshape the expression profiles of PCD-related genes